Widaplik (Telmisartan, Amlodipine, and Indapamide) for High Blood Pressure

Widaplik (telmisartan, amlodipine, and indapamide) is a prescription medication approved by the U.S. Food and Drug Administration (FDA) to treat hypertension (high blood pressure) in adults.

How Widaplik Works and How It’s Taken

Widaplik is a prescription medicine that combines three drugs to treat high blood pressure in adults:

Telmisartan — An angiotensin 2 receptor blocker (ARB) that blocks the effects of a substance in the body that causes blood vessels to tighten
Amlodipine — A calcium channel blocker that helps relax and widen blood vessels
Indapamide — A thiazidelike diuretic, or water pill, that helps the body remove extra salt and water through urine

These three medicines work in different ways to lower blood pressure. Lowering high blood pressure can reduce the risk of serious problems, including stroke and heart attack. However, studies have not shown that Widaplik itself reduces the risk of these events.

Doctors prescribe Widaplik to adults with high blood pressure. It may also be used as the first treatment for people who are likely to need more than one medicine to reach their blood pressure goals.

Widaplik is taken by mouth once a day, with or without food. Swallow the tablet whole. Do not cut, crush, or chew it.

Typical Dosing for High Blood Pressure

The recommended starting dose of Widaplik is either:

10 milligrams of telmisartan, 1.25 milligrams of amlodipine, and 0.625 milligrams of indapamide once daily
20 milligrams of telmisartan, 2.5 milligrams of amlodipine, and 1.25 milligrams of indapamide once daily

Your healthcare provider will choose a starting dose based on how much your blood pressure needs to be lowered. They may increase your dose after two weeks if needed.

The maximum recommended daily dose is 40 milligrams of telmisartan, 5 milligrams of amlodipine, and 2.5 milligrams of indapamide.

For adults aged 65 years or older, healthcare providers may consider starting with the lowest dose.

This information is based on the prescribing information, but your healthcare provider may tailor your treatment plan. Always follow their guidance.

Widaplik Side Effects

In clinical studies of Widaplik, the most common side effects include:

Symptomatic hypotension (feeling dizzy or lightheaded from low blood pressure)

Serious Side Effects and Warnings

Widaplik can cause serious side effects that may require immediate medical attention. These include:

Fetal harm during pregnancy — Medicines like telmisartan that act on the renin-angiotensin-aldosterone system can injure or cause death to a developing fetus.
Hypotension — Low blood pressure can cause fainting, dizziness, or weakness.
Electrolyte and glucose imbalances — Changes in salts like sodium or potassium, or in blood sugar, can cause weakness, confusion, muscle cramps, or abnormal heart rhythms.
Kidney problems — Worsening kidney function may show up as reduced urination, swelling, or unusual fatigue.
Acute angle-closure glaucoma, acute myopia, and choroidal effusion — These conditions involve a sudden increase in eye pressure, sudden changes in vision, or fluid buildup in the eye, respectively, and may lead to permanent vision loss if untreated.
Hyperuricemia — Uric acid levels in the blood may increase, which can cause gout in some people.

Get medical help right away if you think you are having a serious reaction.

This drug has a boxed warning, the FDA's strongest safety warning, for some of the serious risks mentioned above. A boxed warning does not mean the drug is unsafe for everyone or that everyone faces the same level of risk.

If you experience serious side effects, you can report them to the FDA online or by calling 1-800-FDA-1088. You can also contact the drug's manufacturer.

What To Know Before Taking Widaplik

Before starting Widaplik, your doctor may correct low body fluid or low salt levels in your body.

Before taking Widaplik, tell your doctor if you:

Have liver, kidney, or heart problems
Have an imbalance of electrolytes or fluids in your body
Have glaucoma, an eye condition that can damage your vision
Have gout, a condition caused by a buildup of uric acid
Are allergic to sulfonamide or penicillin medicines
Are pregnant, plan to become pregnant, are breastfeeding, or plan to breastfeed

Tell your doctor about all medicines you take, including prescription drugs, over-the-counter medicines, vitamins, and herbal supplements. Widaplik may affect how other medicines work, and other medicines may affect how Widaplik works.

Be sure to tell your doctor if you take:

Aliskiren
Digoxin
Lithium
Nonsteroidal anti-inflammatory drugs (NSAIDs), such as certain pain and inflammation medicines
Simvastatin
Cyclosporine or tacrolimus
Norepinephrine

Do not take Widaplik if you:

Cannot produce urine (anuria)
Are allergic to telmisartan, amlodipine, indapamide, other sulfonamide-type medicines, or any other ingredient in Widaplik
Have diabetes and are taking aliskiren

If you are pregnant or planning to become pregnant, talk with your healthcare provider about other ways to lower your blood pressure. Widaplik can cause serious harm or death to a developing baby. If you become pregnant while taking Widaplik, stop taking it and tell your healthcare provider right away.

Do not breastfeed during treatment with Widaplik. Talk with your healthcare provider about the best way to feed your baby while taking this medicine.

Community FAQs

These answers are fact-checked by our editorial staff.

How effective is Widaplik for high blood pressure?

Clinical studies have shown that Widaplik helps lower blood pressure in adults.

In a four-week study, Widaplik lowered the top blood pressure number (systolic blood pressure) measured at home by 9.6 to 10.4 millimeters of mercury (mmHg), compared with 2.2 millimeters of mercury in people taking a placebo (a pill without active medicine). Most of this effect happened within the first two weeks.

In a 12-week study, people first took Widaplik for four weeks before being placed into different treatment groups. During the next 12 weeks, Widaplik at a dose of 40 milligrams of telmisartan, 5 milligrams of amlodipine, and 2.5 milligrams of indapamide lowered the top blood pressure number by 4.0 millimeters of mercury from the start of that 12-week period. Widaplik lowered blood pressure by 2.5 to 5.4 millimeters of mercury more than the two-drug combinations studied.

How long does Widaplik take to work for high blood pressure?

Almost all of Widaplik’s blood pressure-lowering effect can be seen within two weeks of starting treatment. In one clinical study, most of the reduction in the top blood pressure number measured at home happened during the first two weeks.

What tests or monitoring are needed with Widaplik for heart disease?

Your healthcare provider will monitor your blood pressure during treatment with Widaplik, especially if you are at risk for low blood pressure.

They will also check your kidney function, electrolytes, such as sodium and potassium, and blood sugar levels regularly.

If you take Widaplik with certain medicines, such as digoxin, cyclosporine, or tacrolimus, your healthcare provider will also monitor the levels of those medicines in your blood.