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Baxfendy (baxdrostat) is a prescription medication approved by the U.S. Food and Drug Administration (FDA) for treating hypertension (high blood pressure) in adults whose blood pressure is not well controlled with other medicines.
Baxfendy is a type of aldosterone synthase inhibitor that works by lowering aldosterone, a hormone that makes the kidneys hold on to salt and water. In high blood pressure, this helps reduce extra fluid in the blood vessels and lower blood pressure.
Doctors prescribe Baxfendy with other blood pressure medicines for adults whose high blood pressure is not well controlled with other medicines.
Baxfendy is given as a tablet by mouth, typically once daily. It can be taken with or without food.
The recommended dose of Baxfendy for high blood pressure is 2 milligrams by mouth once daily.
For people at increased risk of high potassium or low sodium, doctors may prescribe 1 milligram by mouth once daily.
This information is based on the prescribing information, but your healthcare provider may tailor your treatment plan. Always follow their guidance.
In clinical trials, Baxfendy was used with other blood pressure medicines to treat high blood pressure in adults. These adults had blood pressure that was not well controlled with other medicines.
The side effects below were reported during 12-week studies. Possible side effects include:
Baxfendy can cause high potassium levels in the blood. It can also cause low sodium levels in the blood.
Your healthcare provider will check your potassium and sodium levels before treatment and from time to time during treatment.
Get medical help right away if you think you are having a serious reaction.
AstraZeneca, the manufacturer of Baxfendy, offers the AZ&Me Prescription Savings Program. AZ&Me provides medications at no cost to eligible people who are prescribed AstraZeneca medications and cannot afford them.
The AZ&Me Prescription Savings Program also offers online tools to check your eligibility and apply. To learn more, visit the AZ&Me site or call 800-292-6363.
Before starting Baxfendy, your doctor will check your blood potassium and sodium levels.
Talk with your healthcare provider before using potassium supplements or salt substitutes that contain potassium during treatment with Baxfendy.
Your healthcare provider may check your potassium more often if you take medicines that can raise potassium levels. They may also monitor Baxfendy’s effects more often if you take certain medicines called strong or moderate CYP3A inducers.
If you miss a dose of Baxfendy, take your next dose at the usual time. Do not take two doses in the same day.
If you are pregnant, planning to become pregnant, or breastfeeding while taking Baxfendy, talk with your doctor about the risks and benefits. It is not known if Baxfendy can harm a fetus. It is also not known if Baxfendy passes into human breast milk.
These answers are fact-checked by our editorial staff.
How effective is Baxfendy?
In a 12-week study, Baxfendy was studied in adults whose high blood pressure was not well controlled with other blood pressure medicines.
At 12 weeks, systolic blood pressure went down by:
Compared with placebo, systolic blood pressure went down by 8.7 mm Hg with 1-milligram Baxfendy and 9.8 mm Hg with 2-milligram Baxfendy.
Diastolic blood pressure also improved. Compared with placebo, it went down by 3.3 mm Hg with 1-milligram Baxfendy and 3.9 mm Hg with 2-milligram Baxfendy.
What tests or monitoring are needed with Baxfendy for heart disease?
Your healthcare provider should check your potassium and sodium levels before you start Baxfendy. They should also check these levels from time to time during treatment.
Any potassium or sodium problems should be corrected before starting Baxfendy.
Your healthcare provider may check your potassium more often if you have a greater risk of high potassium. This includes people age 65 or older, people with diabetes, people with chronic kidney disease, and people taking medicines that can raise potassium.
On MyHeartDiseaseTeam, people share their experiences with heart disease, get advice, and find support from others who understand.
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